Libman–Sacks endocarditis
Libman-Sacks endocarditis is a form of nonbacterial endocarditis that is seen in systemic lupus erythematosus. It is one of the most common cardiac manifestations of lupus (the most common being pericarditis).[1]
It was first described by Drs. Emanuel Libman and Benjamin Sacks at Mount Sinai Hospital in New York City in 1924.[2][3] The association between Libman-Sacks endocarditis and antiphospholipid syndrome was first noted in 1985.
Presentation
The vegetations are small and formed from strands of fibrin, neutrophils, lymphocytes, and histiocytes. The mitral valve is typically affected, and the vegetations occur on the ventricular and atrial surface of the valve. Libman-Sacks lesions rarely produce significant valve dysfunction and the lesions only rarely embolize.[4]
Pathology
The pathology is the same as nonbacterial thrombotic endocarditis except focal necrosis (hematoxylin bodies) can be found only in Libman-Sacks endocarditis.
References
- ^ Libman-Sakcs endocarditis, in Mosby’s Medical, Nursing &Allied Health Dictionary, Fourth Edition, Mosby-YearBook, Inc., 1994, p. 907
- ^ Libman E, Sacks B: A hitherto undescribed form of valvular and mural endocarditis. Arch Intern Med 1924; 33: 701-37.
- ^ Patient.co.uk: Libman-Sacks Endocarditis Retrieved 2008-08-11
- ^ Doherty NE, Siegel RJ: Cardiovascular manifestations of systemic lupus erythematosus. Am Heart J, 1985 Dec;110(6):1257-1265
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anat (h/n, u, t/d, a/p, l)/phys/devp/hist
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noco(m, s, c)/cong(d)/tumr, sysi/epon, injr
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